FOR IMMEDIATE RELEASE: May 21, 2008
Wendy Waldsachs Isett, AUA
AUA 2008: LOW CHOLESTEROL LEADS TO LOWER PSA
ORLANDO, FL, May 21, 2008 – Managing your cholesterol may also help you manage your prostate- specific antigen (PSA) level. Data presented today at the 103rd Annual Scientific Meeting of the American Urological Association from researchers at the Duke Prostate Center, Duke University explored the relationship between total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and PSA prior to beginning statin therapy. Data collected from a study of 1,214 men about to start cholesterol-lowering drugs (statins) between 1990 and 2006 at the
In 2007, a retrospective study from the same group showed that men taking statins to lower their cholesterol also experienced a proportional decline in their PSA levels. This new study confirms that evidence and highlights the fact that cholesterol may play a role in prostate biology. Data was collected from men who were free of prostate cancer, had not undergone prostate surgery or taken medicine to alter androgen levels, and whose PSA was between 0.1 and 10.0 ng/ml.
“These findings further affirm the idea that a heart-healthy lifestyle can also be a prostate-healthy lifestyle,” said Stephen J. Freedland, M.D., one of the study’s authors. “Indeed, monitoring your cholesterol could be a means to keeping your PSA at a lower level.”
“Though the observed change in PSA across different cholesterol levels in this group of men is unlikely to impair the use of PSA to test for prostate cancer,” commented the study’s lead author, Dr. Robert J. Hamilton, M.D., M.P.H, “this issue clearly warrants further study.” It remains to be seen whether or not lowering your PSA through statin medications could potentially mask the presence of prostate disease. The results of this study indicate that cholesterol and PSA are valuable indicators of overall health for men and should continue to be monitored together.
NOTE TO REPORTERS: Experts are available to discuss these studies outside normal briefing times. To arrange an interview with an expert, please contact the AUA Communications Office at the number above or e-mail Wendy Isett at firstname.lastname@example.org.
Hamilton RJ, Platz EA, Goldberg KC, Freedland SJ: The association between cholesterol and PSA. J Urol, suppl., 2008; 179: 721, abstract 2094.
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