Clinical features: Typically a disease of young adults; most cases are sexually transmitted.
Incubation period: variable, ranging from weeks to months to years.
Gross features: flat, warty or papillary lesions usually on glans or penile meatus, but may be seen on scrotum, and perineum as well as perianal region.
Histologic features:
Hyperkeratosis (thickened keratin layer), parakeratosis (pyknotic nuclei within the keratin layer) and koilocytes (raisin-oid cells within a clear "halo") are characteristic features.
penile condylomas are usually cytologically benign, although treatment with podophyllin or lasers may cause marked cytologic atypia – a history of prior treatment is therefore always appreciated.
viral strains 6 and 11 are common in typical condyloma without dysplasia, while strains 16, 18, 31 and 33 are more common in the dysplastic forms of condyloma.
Prognosis and treatment: may spontaneously regress (50%); otherwise treat with podophyllin or laser.
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