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Erythroplasia of Queyrat
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- Clinical: usually men in 5th-6th decades. (median = 51 years); much less common in circumcised men.
- Gross features: bright red, glistening, velvety plaque on the glans and the prepuce; may also involve urethral meatus, frenulum , or neck of the penis.
- Histologic features:
- essentially represents squamous carcinoma in situ (full thickness involvement by neoplastic cells with loss of maturation, etc.)
- underlying dermis may contain dense chronic inflammatory infiltrate with vascular proliferation
- Prognosis: 10% of patients progress to invasive squamous cell carcinoma, and 2% develop distant metastases.
- Differential diagnosis (clinical): Zoon’s balanitis, drug eruptions, psoriasis, lichen planus, and other inflammatory processes.
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