Main Menu Pathology | Prostate I - [click on image(s) below] Prostatic Hyperplasia Most common urologic disease of men Clinical: smoothly enlarged prostate; begins at 20-30 yrs and increases steadily after age 40; obstructive voiding symptoms are most common Etiology: unknown -- most likely androgen stimulation with estrogen synergism Pathogenesis: two factors play a role: increased smooth muscle tone and obstruction Location: McNeal states that hyperplasia does not occur outside of the pre-prostatic tissue (transition zone is particularly guilty) Histologic features: both glands and stroma can become hyperplastic cytologically benign with two cell layers, bland nuclei and abundant cytoplasm corpora amylacea may be identified (laminated eosinophilic concretions within the lumen of the gland) nonspecific chronic lymphocytic infiltrate is common