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Prostatic Intraepithelial Neoplasia (PIN)
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- Generally accepted as the probably precursor lesion for many cases of prostatic carcinoma
- Divided into low grade (mild dyplasia/ grade I) and high grade (moderate dysplasia/ grade 2 and severe dysplasia/ grade 3)
- High grade PIN is a marker for cancer
- Histologic features:
- on low power, the glands appear large and complex, but more basophilic (blue) than the normal glands of BPH
- basal cells are present, if only focally
- high power shows prominent nucleoli, nuclear crowding and pseudostratification (piling up of the nuclei)
- also: the papillary structures at low power turn out to be caused by the cellular pile-up; in BPH, the papillary structures actuallly have fibrovascular cores and therefore are true papillae...
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