Main Menu Pathology | Prostate II - [click on image(s) below] Prostatic Adenocarcinoma, Gleason’s Grade 1 Tumor is composed of circumscribed nodules of uniform, closely-packed glands Nuclei may have inconspicuous nucleoli -- but remember that cytology is not a criteria in the Gleason’s system. Only architecture is important, so the diagnosis is often a low-power diagnosis. Glands tend to be slightly larger than those seen in the higher grade cancers Cells have abundant eosinophilic cytoplasm The diagnosis is virtually never made on a needle biopsy, because these low-grade carcinomas most often involve the transition zone Caveat: Even Gleason questioned whether the so-called “grade 1 carcinoma” was really cancer. So be wary about making this diagnosis...