Pathology | Renal Cystic Diseases - [click on image(s) below]
Renal Dysplasia
Gross: cystic kidneys without loss of reniform contours; may be segmental, unilateral, or
bilateral (shown); 90% have associated ureteral abnormality
Histology: three classic features to look for:
"cuffs" of spindle cells around primitive or fetal-appearing tubules
Islands of cartilage
Loss of the normal renal architecture
Etiology: two theories have been proposed:
urinary tract obstruction in utero (may or may not play a role)
fundamental defect in the inducer tissue (ureteric bud) or the responding tissue (metanephric blastema)
Syndromes: usually sporadic but may be associated with hereditary syndromes involving multiple malformations
Potter’s classification: Type IIa (multicystic renal dysplasia), Type IIb (aplastic renal dysplasia) and type IV (dysplasia resulting from lower tract obstruction)
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