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Pathology | Renovascular Disease - [click on image(s) below]

Malignant Hypertension

  1. Occurs in 1-5% of hypertensive patients: can develop in previously healthy patients but is more often superimposed on preexisting benign hypertension or chronic renal disease
  2. Etiology is variable, but the clinical course is severe and -- if left untreated -- has a rapidly downhill progression
  3. Gross: dependent on the duration and severity of the hypertensive disease; small petechial hemorrhages give a flea-bitten appearance to the kidneys.
  4. Microscopic features:
    • interlobular arteries and arterioles demonstrate densely eosinophilic material representing fibrinoid necrosis of the vessel walls
    • "onion-skin" appearance of vessel walls
    • microthrombi may be present