Pathology | Renal Tumors I - [click on image(s) below]
Clear Cell Sarcoma
Age: 1-3 years
Associations: none.
This tumor is at least 10 times as likely to metastasize to bone as any other pediatric renal tumor, so it is sometimes referred to as the “bone metastasizing tumor of childhood”
Clinical features: 66% of patients are male
Gross: variable: may be homogeneous gray and lobular, or may be firm and light pink with whorled areas; usually well-circumscribed; bilaterality has not been reported
Histology:
cells have lightly-staining cytoplasm (not optically clear as in renal cell carcinoma)
cells are arranged in cords or packets separated by fibrovascular septa with “chicken-wire” appearance
typically has infiltrative borders
Prognosis: death rate = 30-40% with chemotherapy; late recurrences do occur.
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 helps to distinguish it from the other clear cell renal tumor, a renal cell carcinoma, in which the cells are water-clear'))
 helps to distinguish it from the other clear cell renal tumor, a renal cell carcinoma, in which the cells are water-clear'))