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Pathology | Renal Tumors I - [click on image(s) below]

Mesoblastic Nephroma: Classical form

  1. Age: <3 months; uncommon after 6 months
  2. Associations: polyhydramnios and prematurity
  3. Gross: relatively large tumor with a firm white whorled cut surface; unencapsulated
  4. Histology:
    1. moderately cellular spindle-cell neoplasm with elongated nuclei
    2. margins are infiltrative, with cells extending into the adjacent renal and perirenal tissues
    3. although cellular, this neoplasm typically has very few mitotic figures (0-1 per 10 high-power fields)
  5. Clinical behavior: surgical resection is invariable curative.
  6. Adverse prognostic indicators: age > 3 months; incomplete resection; ? cellular histologic pattern