Main Menu Pathology | Renal Tumors II - [click on image(s) below] Renal Cell Carcinoma Cytogenetics: 3p-, 5q+ Associations: von Hippel-Lindau disease Tuberous Sclerosis Autosomal dominant polycystic kidney disease Acquired cystic renal disease ? familial RCC Gross: golden yellow tumor with hemorrhage and necrosis; +/- cystic changes Microscopic: water-clear cells in "chicken wire" vasculature the delicate capillary structure often ruptures during surgical manipulation, resulting in the formation of “blood lakes” some cells may have granular eosinophilic cytoplasm (used to be called “granular cell RCC”, but that term is no longer used). Nuclear grading based on Fuhrman classification (grades I-IV).