Pathology | Renal Tumors II - [click on image(s) below]
Chromophobe Renal Cell Carcinoma
Cytogenetics: Loss of chromosomes, but NOT 3p-
Gross: solitary, solid, beige or light brown, well-circumscribed
Histology:
cells have flocculent cytoplasm that condenses around the edges of the cell, contributing to the appearance of thick prominent cell borders
I have found that the nuclei tend to be much more pleomorphic than is seen in a typical clear cell renal cell carcinoma or an oncocytoma (which is the main differential diagnosis in this case).
Hale’s colloidal iron stain is positive in chromophobe renal cell carcinoma (cells stain bright blue), but negative in clear cell RCC and in oncocytoma.
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