Pathology | Testis III - [click on image(s) below]
Leydig Cell Tumor
Comprise 1-3% of testicular tumors and are sometimes seen in association with Klinefelter’s syndrome
Clinical: may be associated with cryptorchidism; 3% bilateral; endocrine symptoms due to increased levels of estrogen and/or androgens have been reported; adults often present with testicular mass and gynecomastia; children present with precocious pseudopuberty (“pseudo” because they get secondary sex characteristics but there is no spermatocytic maturation); symptoms usually regress following resection
Gross: solid brown nodules within the testicular parenchyma; average size 3.0 cm
Histologic features:
tumor cells have abundant eosinophilic cytoplasm with well-defined cytoplasmic borders
may have intracellular eosinophilic crystalloids (crystals of Reinke)
giant atypical nuclei may be seen and do not indicate malignancy
malignant features include large size (> 7.5 cm), necrosis, high mitotic rate, and blood vessel invasion
)
)
)
)