Pathology | Testis III - [click on image(s) below]
Sertoli Cell Tumors
Sertoli cell hyperplasia may be seen with cryptorchid testes and may be manifestation of abnormal sexual maturation
Sertoli cell adenomas may be seen in patients with testicular feminization
Sertoli cell tumors: -- may be associated with gynecomastia in 30% of cases
Gross features: gray white lesions with well-circumscribed borders and focal cystic areas
Histologic features:
tubules lined by elongated “wind-swept” cells with hyperchromatic nuclei and clear wispy cytoplasm
solid areas may look like seminomas
features favoring malignancy include: high mitotic rate, pleomorphic cells, large tumor size, necrosis
Treatment: orchiectomy +/- chemo/ radiation in malignant cases
Variations: Sclerosing Sertoli cell tumor (no estrogen production so no gynecomastia -- these tumors are invariably benign) and large cell calcifying Sertoli cell tumor (seen in young patients < 20 years old and part of a syndrome including dermal pigmentation, cardiac myxomas, pituitary tumors, etc.)
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