American Urological Association - Reactive Transitional Cells

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Reactive Transitional Cells

Image A

Image B

  • Once again, the first thing to do is establish how the specimen is received. One clue (image A) is the dense purple "blob" at the right side of the picture: this represents K-Y jelly; therefore, we can assume these are washings/brushings.
  • Cytologic features to look for:
    • Cells maintain smooth, round nuclear borders with evenly distributed chromatin (image B).
    • Nuclei may be slightly enlarged with small punctate cherry-red nucleoli.
    • Binucleation and multinucleation is common, especially in the umbrella cells.
    • Clusters and sheets do not have fibrovascular cores.
    • Cells still "respect" each other's borders.
    • Background is relatively clean, without necrosis or debris.

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