American Urological Association - Lipogranuloma
- So known as paraffinoma, sclerosing lipogranuloma, and Tancho's nodules.
- Clinical: usually seen in men <40 years; localized mass or indurated plaque that may be tender to palpation.
- Penile lesions are usually due to injection of paraffin, silicone, oil, or wax (purportedly for sexual gratification or penile enlargement).
- Scrotal lesions are usually due to injection of foreign material, trauma, cold weather, and topical application of ointment.
- The lesion consists of lipid vacuoles embedded in a sclerotic stroma.
- Often accompanied by a granulomatous reaction with foreign-body giant cells.
- Diagnosis may be confirmed by doing lipid stains.
- Differential diagnosis: malakoplakia or signet ring carcinoma.