American Urological Association - Bowenoid Papulosis
- Clinical: multiple papules in anogenital region of young men that histologically resemble squamous cell carcinoma in situ.
- Most often related to HPV 16.
- Usually transmitted sexually.
- Younger patients than PEIN (30's to 40's).
- Gross: usually occur on penile shaft; papules range from 0.2 to 1.0 cm; sometimes coalesce to form plaques like condyloma acuminatum.
- Proliferation of atypical basaloid cells and koilocytic change can be seen (image A) & (image B). (Resemble HPV-related PEIN).
- May involve sweat gland (unlike PEIN).
- Usually spare the pilosebaceous units (unlike PEIN).
- Most have benign course and may undergo spontaneous regression.
- Minority may progress to SCC; but mainly considered not precancerous.