American Urological Association - Intimal Fibroplasia


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Intimal Fibroplasia

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  • Primary
    • Least common form of the dysplasias (<1%)
    • Adult and childhood forms have been described.
    • Histology: Circumferential or eccentric accumulation of loose moderately cellular fibrous tissue inside (internal elastic lamina) without lipid or inflammation, expanding the intima (image A) and (image B).
    • Arteries of limbs and GI tract may show similar changes.
  • Secondary
    • Occurs in the more distal branches of the renal artery
  • May be associated clinically with chronic pyelonephritis and end-stage renal disease