American Urological Association - Spermatocytic Seminoma
Home Education AUAUniversity Education Products & Resources Pathology for Urologists Testis Germ Cell Tumors Spermatocytic Seminoma

Spermatocytic Seminoma

Image A

Image B

  • Extremely rare; older patients than other GCT (mean 54 years).
  • Does not arise from ITGCN and is not associated with cryptorchidism.
  • Serum tumor markers (AFP, HCG and LDH) are not elevated.
  • Higher chance for bilaterality (up to 9%).
  • No race predilection in contrast to other GCT.
  • Unlike other testicular GCTs, has no counterpart in female ovary.
  • Gross: well circumscribed, multinodular, soft and mucoid or gelatinous mass.
  • Histology:
    • Composed of 3 cell types (Hallmark is polymorphism) (image A) & (image B).
    • Small lymphocyte-like cells: (6-8 µm) with smudged, degenerated appearance and scant cytoplasm.
    • Intermediate cells: (15-20 µm) with round nucleus and granular chromatin and modest cytoplasm.
    • Giant cells: (50-100 µm) with one or more nuclei, and demonstrate filamentous or "spireme-type" chromatin.
  • Vast majority with excellent prognosis; malignant behavior in <1%.