American Urological Association - Urothelial Dysplasia
- Atypical cytologic and architectural features felt to be neoplastic that fall below the threshold for CIS.
- Suffers from poor diagnostic reproducibility.
- Nuclear abnormalities in the absence of inflammation, or disproportionate in the presence of inflammation, but not severe enough to merit CIS (image A) & (image B).
- Usually normal urothelial thickness.
- Mild loss of polarity and nuclear crowding.
- Immunohistochemistry: may aberrantly express CK20 and have higher p53+.
- On follow-up, 5-19% progress to bladder neoplasia including CIS.