American Urological Association - Mucinous Tubular and Spindle Cell Carcinoma
Mucinous Tubular and Spindle Cell Carcinoma
- Renal carcinoma that shows an unusual growth of having biphasic pattern of tubular and spindled epithelial cells and with mucinous stroma.
- Uncommon, female>male (4:1).
- Majority discovered incidentally.
- Multiple chromosomal losses involving 1, 4q, 6, 8p, 11q, 13, 14 and 15, and gains involving 11q, 16q, 17, and 20q.
- Gross: Well-circumscribed tumor with gray-white to tan cut surface.
- Morphologic and immunohistochemical overlap with sarcomatoid papillary type 1 RCC (main DDX).
- Tubular cells may look similar + spindle cells in sarcomatoid change.
- Both tumors are CK7+ and AMACR+.
- However, papillary RCC lacks extracellular mucin and shows trisomy 7 and 17. (Distinction is often morphologic)
- Mostly have good prognosis. (Distinction from the more aggressive sarcomatoid papillary RCC is thus important)