American Urological Association - Liposarcoma
- Most common sarcoma of paratesticular tissue in adults (followed by leiomyosarcoma).
- Bulky paratesticular/testicular mass with yellow fatty appearance.
- Most often lipoma-like or well-differentiated liposarcoma. (Identifiable neoplastic fat cells are abundant) (image A).
- Contain lipoblasts (large multivacuolated cell with pleomorphic nuclei and the nucleus is indented by the vacoulations) (image B).
- Rarely may undergo high-grade dedifferentiation to spindle cell morphology.
- Has prolonged clinical course with recurrences in >50%.
- No metastasis in well-differentiated tumors.