EDUCATION > Educational Programs > E-Learning > Pathology for Urologists

Pathology for Urologists

Paraganglioma


Image A
(click on the image above)

Image B
(click on the image above)

  • Also known as pheochromocytoma of bladder, and is thought to arise from paraganglion tissue within the bladder.
  • Most common presenting symptom is hematuria, although the pathognomonic finding is paroxysmal hypertension with micturition.
  • Gross features: intramural nodules <5 cm in size, usually with intact overlying mucosa (image A).

Image C
(click on the image above)

Image D
(click on the image above)

  • Histology:
    • Essentially look like paragangliomas elsewhere (think of pheochromocytoma in adrenal gland).
    • Nested growth ("zellballen") of cells with abundant eosinophilic cytoplasm and indistinct cytoplasmic borders (image B) & (image C).
    • Mitoses are rare and necrosis is absent
    • Nuclear atypia may be seen and does not imply a worse prognosis.
  • Immunohistochemistry: positive for neuroendocrine markers synaptophysin (image D) and chromogranin; S100 will stain intermingled sustentacular cells.
  • Majority is benign (90%), but local recurrence may occur with incomplete excision.

ADVERTISEMENT

ADVERTISEMENT
Donate
Contact
Press/Media
Sections
Term of Use
Site Map


ADVERTISEMENT