EDUCATION > Educational Programs > E-Learning > Pathology for Urologists

Pathology for Urologists

Epithelioid Angiomyolipoma


Image A
(click on the image above)

Image B
(click on the image above)

  • Angiomyolipoma with predominant epithelioid morphology.
  • Like triphasic AML, some are associated with tuberous sclerosis and tuberous sclerosis complex genes.
  • Tumors in tuberous sclerosis tend to be large, multifocal and presents at younger age.
  • Histology:
    • Cohesive cells in nests or alveolar growth separated by thin septa and blood vessels ("carcinoma-like growth") (image A).
    • Spindle and epithelioid cells with fewer blood vessels (image B).
    • "Clear cells" with granular cytoplasm or eosinophilic cells (image C)
    • Nuclei appear high grade (image D) and mitosis is common.
    • Multinucleated pleomorphic giant cells.

Image C
(click on the image above)

Image D
(click on the image above)

  • Immunohistochemistry:
    • Melanoma markers+ (HMB45+, Mart1+).
    • Muscle markers+ (smooth muscle actin+, desmin+) in spindle cells.
  • Unlike AML may recur and some cases metastasize and thus considered to be potentially malignant.
  • DDX:
    • Clear cell RCC: because of the clear cells and cohesive growth, but is epithelial marker keratin+ and melanoma marker-.

ADVERTISEMENT

ADVERTISEMENT
Donate
Contact
Press/Media
Sections
Term of Use
Site Map


ADVERTISEMENT