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Pathology for Urologists

Papillary Cystadenoma of Epididymis (PCE)


Image A
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Image B
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  • 1/3 associated with von Hippel-Lindau disease, in which cases tumors are often bilateral.
  • ~1/5 of patients with von Hippel-Lindau disease have PCE
  • .
  • Usually occurs in younger adult males.
  • Originates from the efferent ductules of the head of the epididymis.
  • Mainly present with a slowly growing painless mass.
  • Gross: Well circumscribed masses measuring 1-5 cm; may appear solid or cystic.
  • Histology:
    • Intracystic papillary infoldings lined by columnar cells with abundant clear cytoplasm (image A) & (image B).
  • May resemble clear cell RCC because of the clear cytoplasm.
  • Excellent prognosis.

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