Pathology for Urologists
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- Agent: Chlamydia trachomatis, subtypes L1, L2, and L3.
- Appearance: intracellular organisms.
- Clinical: 3 stages:
- Primary (genital): papule → pustule formation on the genitals, following 0.5 - 6-week incubation period.
- Secondary (inguinal): painful inguinal lymphadenopathy (bubo), usually unilateral, with abscess formation and rupture in 1/3 of cases.
- Tertiary: genital ulcers, fistulas, elephantiasis, and rectal strictures
Transmission: sexual (rare in the US: more often seen in Africa, Asia, and South America.
- Histology: nonspecific; diagnosis depends upon culture and identification of the organism.
- Treatment: antibiotics, as long as they are administered early in the course of disease.
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