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Pathology for Urologists

Lymphogranuloma Venereum


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  • Agent: Chlamydia trachomatis, subtypes L1, L2, and L3.
  • Appearance: intracellular organisms.
  • Clinical: 3 stages:
    • Primary (genital): papule → pustule formation on the genitals, following 0.5 - 6-week incubation period.
    • Secondary (inguinal): painful inguinal lymphadenopathy (bubo), usually unilateral, with abscess formation and rupture in 1/3 of cases.
    • Tertiary: genital ulcers, fistulas, elephantiasis, and rectal strictures
      Transmission: sexual (rare in the US: more often seen in Africa, Asia, and South America.
  • Histology: nonspecific; diagnosis depends upon culture and identification of the organism.
  • Treatment: antibiotics, as long as they are administered early in the course of disease.

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