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Pathology for Urologists

Fournier's Gangrene


Image A
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Image B
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  • Necrotizing fasciitis of the subcutaneous tissue and skeletal muscle of the genitals and perineum, especially the scrotum (image A).
  • Causative agents: staphylococcal or streptococcal species.
  • Clinical: lesions begin as reddish plaques with necrosis; often associated with systemic symptoms, including pain and fever.

Image C
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Image D
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  • Predisposing factors: diabetes mellitus, immunosuppression, alcoholism, recent surgical intervention, trauma, and morbid obesity.
  • Histologic features: nonspecific: essentially acute inflammatory infiltrate with necrotic tissue and bacteria (image B), (image C), & (image D).
  • Treatment: surgical intervention, antibiotics; may be life-threatening.

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