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Pathology for Urologists

Peyronie's Disease


Image A
(click on the image above)

Image B
(click on the image above)

  • Clinical: Affects men between 20-80 yrs; presents with painful erection accompanied by distortion, bending, or constriction of the erect penis; usually have palpable nodules or plaques on the dorsal surface of the erect penis.
  • Histology:
    • Fibrosis of the tunica albuginea which does not affect the corpora cavernosa.
    • Fibrous tissue may look like simple fibrosis or may resemble fibromatosis (image A) & (image B).
    • The fibrous plaques may become calcified or ossified (os penis).
    • Early lesions demonstrate perivascular inflammation in the loose connective tissue between the tunica albuginea and the sinusoids of the corpora cavernosa.
  • Prognosis and treatment:
    • 30% resolve spontaneously; 40% progress; 30% remain stable.
    • Treatment with surgical excision of plaques, radiotherapy, and steroid injections.

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