Clinical: Affects men between 20-80 yrs; presents with painful erection accompanied by distortion, bending, or constriction of the erect penis; usually have palpable nodules or plaques on the dorsal surface of the erect penis.
Fibrosis of the tunica albuginea which does not affect the corpora cavernosa.
Fibrous tissue may look like simple fibrosis or may resemble fibromatosis (image A) & (image B).
The fibrous plaques may become calcified or ossified (os penis).
Early lesions demonstrate perivascular inflammation in the loose connective tissue between the tunica albuginea and the sinusoids of the corpora cavernosa.