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Pathology for Urologists

Sertoli Cell-Only Syndrome


  • Patients present with normal external genitalia, well-developed secondary sex characteristics, and azoospermia.
  • Elevated FSH, normal/elevated LH, and normal/low testosterone.
  • Histology:
    • Seminiferous tubules contain only Sertoli cells with rare scattered spermatogonia.
    • Low-power impression is a "wind-swept" appearance to the tubules
    • Five variants have been described, based upon the nature of the Sertoli cells.

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