EDUCATION > Educational Programs > E-Learning > Pathology for Urologists

Pathology for Urologists

Carcinoid Tumor (Monodermal Teratoma)

Image A
(click on the image above)

Image B
(click on the image above)

  • Carcinoid of the testis is considered a monodermal teratoma.
  • 20% are associated with other teratomatous elements.
  • In general occurs in older patients than GCT (10-83 years, mean 46).
  • Carcinoid syndrome is rare, but when it occurs it predicts increased likelihood of metastatic disease.
  • Serum AFP and HCG are normal; 5-HIAA elevated
  • Gross: solid well-circumscribed yellow-tan nodule; cystic component
  • Histology:
    • Monotonous cells with abundant eosinophilic cytoplasm and characteristic "salt and pepper" chromatin (image A) & (image B).
    • Growth pattern is nested, or may show a "ribbon and festooning" appearance.
    • ITGCN rare in pure carcinoid.
  • Immunohistochemistry: neuroendocrine markers synaptophysin+ and chromogranin+
  • DDX: primary testicular carcinoid (20% with teratomatous elements) vs. metastatic carcinoid (bilateral, microvascular invasion, and extratesticular involvement).
  • Prognosis excellent with localized disease; excision is curative.


Term of Use

© 2017 American Urological Association Education and Research Inc. All Rights Reserved.