EDUCATION > Educational Programs > E-Learning > Pathology for Urologists

Pathology for Urologists

Granulosa Cell Tumor (GCT)


Image A
(click on the image above)

Image B
(click on the image above)

  • Resembles female ovarian counterpart.
  • Divided into Adult GT and Juvenile GT.
  • Exceedingly rare in testis, but yet juvenile GCT is the most common testicular tumor in infants <6 mos.
  • Adult GT occurs in patients 16 to 76 years (ave. 44 years)
  • Histology:
    • Granulosa cells: relatively uniform round, ovoid or carrot-shaped cells with scant, light staining cytoplasm, nuclear groove (coffee bean).
    • Adult GT: Call-Exner bodies (tumor cells in ring-like or rosette-like arrangement)
      (image A) & (image B).
    • Juvenile GT: variably sized follicles lined by granulosa cells and outer theca cells containing basophilic to faintly eosinophilic luminal materials. Lacks Call-Exner bodies and nuclear grooves.
  • Most tumors have benign behavior; 20% metastasize.

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