EDUCATION > Educational Programs > E-Learning > Pathology for Urologists

Pathology for Urologists

Large Cell Calcifying Sertoli Cell Tumor (LCCSCT)


Image A
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Image B
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  • Variant of SCT characterized by peculiar calcifications admixed with large epithelioid cells.
  • Extremely rare.
  • Usually younger patients, age 1.5-48 years old (ave. 16 years).
  • Slowly growing painless testicular mass.
  • Higher frequency of bilaterality (40%) and multifocality (60%) among SCTs.
  • Most occur as sporadic tumors (60%) or in patients with Carney syndrome and Peutz-Jeghers syndrome.
    • Carney syndrome includes cardiac or cutaneous myxomas, lentigines, mucocutaneous blue nevi, and endocrine overactivity and tumors.
    • Peutz-Jeghers syndrome includes hamartomatous intestinal polyps and mucocutaenous macular hyperpigmentation.
  • Patients may have gynecomastia or precocious puberty.
  • Histology:
    • Hallmark: wavy or irregular laminated nodular calcifications or small psammoma bodies
      (image A) & (image B).
    • Large polygonal cells with abundant pink, "ground-glass" or finely granular cytoplasm.
    • Growth patterns: nests, cords, trabecular, or solid tubules.
  • Majority has good prognosis; 20% malignant.

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