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Classification of Neuroblastic Tumors

(by International Neuroblastoma Pathology Committee)

Image A

Image B

  • Neuroblastoma (Schwannian stroma-poor neuroblastic tumor)
    • Undifferentiated
    • Poorly differentiated
    • Differentiating
  • Ganglioneuroblastoma, nodular (composite Schwannian stroma-rich/stroma-dominant and stroma-poor neuroblastic tumor) (image A) & (image B)
  • Ganglioneuroblastoma intermixed (Schwannian stroma-rich neuroblastic tumor)

Image C

Image D

  • Ganglioneuroma (Schwanian-stroma dominant NT) (image B) & (image C)
    • Maturing
    • Mature
  • Determined by proportion of mature (ganglion cells) versus immature cells (neuroblasts) and amount of Schwannian stroma.
  • Prognosis: favorable histology for ganglioneuroblastoma intermixed and ganglioneuroma and unfavorable histology for ganglioneuroblastoma, nodular.
  • Ganglioneuroma: only <30% are in adrenal gland and majority occurs in the retroperitoneum and mediastinum.