Home Education AUAUniversity Education Products & Resources Pathology for Urologists Kidney Mesenchymal and Other Tumors Lymphoma


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  • Kidney is often involved secondarily by systemic lymphoma, especially non-Hodgkin's lymphomas with extensive retroperitoneal disease.
  • Primary renal lymphoma, however is rare.
  • The most common primary renal lymphoma is post-transplant lymphoproliferative disorder or PTLD.
  • Renal involvement by lymphoma generally does not clinically manifest.
  • Gross: large "fish-flesh" nodules or diffuse expansion and infiltration of the kidney (image A).

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  • Histology: diffuse lymphoid infiltration with tubule and glomerular sparing (image B) & (image C).
  • IHC:
    • Neoplastic lymphoid cells lineage can be identified by immunostains such as CD20 (for B-cells), CD3 (for T-cells), CD56 (for NK-cells) and CD30 (for Reed Sternberg cells in Hodgkin's disease).
    • Overwhelming predominance of CD20 or CD3 is supportive of monoclonality for that lineage (image D).