Home Education AUAUniversity Education Products & Resources Pathology for Urologists Normal Histology and Important Histo-anatomic Structures Seminal Vesicles

Seminal Vesicles

Image A

Image B

  • Secrete alkaline fluid (containing fructose, fibrinogen, and vitamin C) that contributes to the nutritive and supportive fluid of semen (~65%).
  • Histology:
    • Has irregular lumen that contains papillae and glands that exhibit "honeycomb" appearance
      (image A)
    • Lined by pseudostratified cuboidal to columnar cells and basal cells.
    • Contains pseudomalignant pleomorphic cells ("monster cells") and cytoplasmic golden-yellow lipofuscin pigments (image B, arrows).
      • Another example of benign GU cell that is pleomorphic!
      • Pleomorphic large cells and abundant lipofuscin are unusual in prostate cancer, so distinction in biopsy is usually not that difficult.
  • Has thick inner circular and thin outer longitudinal fibromuscular wall layers.

Image C

Image D

  • SV excretory duct joins the vas deferens to form the ejaculatory duct (ED), which travels through the prostatic central zone and exits into the urethra (image C).
  • SV and ED have similar cell lining (image D).
  • Prostate cancer spreads to SV most often via the ED.