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Home Education AUAUniversity Education Products & Resources Pathology for Urologists Penis Infections Herpes Simplex

Herpes Simplex

Image A

Image B

Agent: herpes simplex virus, type 2.
Clinical: pain, itching, ulcers, urethral discharge, dysuria, and tender lymphadenopathy.
Transmission: sexual.
Histology:
- Vesicles with multinucleated giant cells containing intranuclear inclusions surrounded by clear halos (image A) & (image B).
- Tzanck prep highlights these viral-laden cells.
Treatment: acyclovir eases the symptoms and decreases the duration of recurrences, but there is no cure.