Home Education AUAUniversity Education Products & Resources Pathology for Urologists Penis Inflammatory and Tumor-like Lesions Fournier's Gangrene

Fournier's Gangrene

Image A

Image B

  • Necrotizing fasciitis of the subcutaneous tissue and skeletal muscle of the genitals and perineum, especially the scrotum (image A).
  • Causative agents: staphylococcal or streptococcal species.
  • Clinical: lesions begin as reddish plaques with necrosis; often associated with systemic symptoms, including pain and fever.

Image C

Image D

  • Predisposing factors: diabetes mellitus, immunosuppression, alcoholism, recent surgical intervention, trauma, and morbid obesity.
  • Histologic features: nonspecific: essentially acute inflammatory infiltrate with necrotic tissue and bacteria (image B), (image C), & (image D).
  • Treatment: surgical intervention, antibiotics; may be life-threatening.