Home Education AUAUniversity Education Products & Resources Pathology for Urologists Prostate Adenocarcinoma Prostatic Adenocarcinoma: Gleason Pattern 5

Prostatic Adenocarcinoma: Gleason Pattern 5

Image A

Image B

  • No gland formation is evident.
  • Solid sheets (image A).
  • Single cell infiltration (image B).

Image C

Image D

  • Comedonecrosis – glands with central necrosis (image C).
  • Cribriform glands with central necrosis (image D). (pay attention to necrosis)
  • Particularly the solid sheets can be difficult to distinguish from poorly differentiated urothelial carcinoma (urothelial carcinoma is HMWK+ and p63+ and PSA- and PSAP-).