Home Education AUAUniversity Education Products & Resources Pathology for Urologists Urinary Bladder Non-Neoplastic Lesions Cystitis Glandularis

Cystitis Glandularis

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Image B

  • Reactive glandular metaplasia of epithelium found in 71% of bladders, most often as an incidental finding.
  • When visualized, by cystoscopy appears as red raised nodular lesions, with predilection for trigone.
    • Rarely, extensive intestinal metaplasia may have copious mucin extravasation that may form pseudotumorous mass lesion.
  • Histology: 2 histologic types.
    • Typical type: similar to cystitis cystica but with luminal cuboidal or columnar cells surrounded by urothelial cells (image A) & (image B).

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  • Intestinal type: identical to typical cystitis glandularis but with presence of goblet cells
    (image C) & (image D).
  • In patients with long-standing inflammation (indwelling catheters, calculi, etc.), intestinal type cystitis glandularis may become diffuse, at which time is suggested as a possible risk for bladder adenocarcinoma, although this association is currently controversial.