American Urological Association - Adrenal Gland: Medulla
Adrenal Gland: Medulla
- Central part of adrenal that arose from neural tissue (image A).
- Rich in blood vessels.
- Predominant cell is the chromaffin cell.
- Neuroendocrine cell that produces catecholamines (epinephrine and norepinephrine).
- Has brownish appearance with chromium salts due to oxidation of catecholamines to melanin (hence the name "chromium" + "affinity").
- Columnar cells with basophilic (bluish) granular cytoplasm arranged in clusters usually around vessels (image B).
- Expresses synaptophysin and chromogranin.
- Few ganglion cells are also present.
- Large round or polygonal cells with abundant cytoplasm, large nuclei and prominent nucleolus (owl's eyes nucleus).