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Pathology for Urologists

Squamous Cell Carcinoma

Image A
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Image B
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  • Represents 5% of bladder tumors, and is associated with chronic inflammatory conditions (calculi, diverticula, cord bladder, and schistosomiasis).
  • Cytologic features:
    • Frequently present as invasive ulcerated lesions, so cytology specimens tend to have a bloody inflammatory background with lots of necrotic debris.
    • Cells usually have dense or "hard" pink cytoplasm (keratinized) and large hyperchromatic nuclei (image A) & (image B).

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