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Pathology for Urologists

Tubulocystic Carcinoma


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  • Renal carcinoma characterized by pure tubular and cystic growth.
  • Originally thought to be "low grade collecting duct carcinoma" because this feature can be seen occasionally in collecting duct carcinoma; exact relationship though is unclear.
  • Rare, with strong male predominance (M:F =7:1).
  • Majority are asymptomatic incidental tumors.
  • Gross: well-circumscribed tumor with "bubble wrap" appearance because of the abundant cysts.

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  • Histology:
  • Limited data on follow-up, suggested as less aggressive.
  • Differential diagnosis:
    • Multilocular cystic RCC: lined by clear cells and is CAIX+.

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