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Pathology for Urologists

Seminal Vesicles (SV)


Image A
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Image B
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  • Secrete alkaline fluid (containing fructose, fibrinogen, and vitamin C) that contributes to the nutritive and supportive fluid of semen (~65%).
  • Histology:
    • Has irregular lumen that contains papillae and glands that exhibit "honeycomb" appearance
      (image A)
      .
    • Lined by pseudostratified cuboidal to columnar cells and basal cells.
    • Contains pseudomalignant pleomorphic cells ("monster cells") and cytoplasmic golden-yellow lipofuscin pigments (image B, arrows).
      • Another example of benign GU cell that is pleomorphic!
      • Pleomorphic large cells and abundant lipofuscin are unusual in prostate cancer, so distinction in biopsy is usually not that difficult.
    • Has thick inner circular and thin outer longitudinal fibromuscular wall layers.

Image C
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Image D
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  • SV excretory duct joins the vas deferens to form the ejaculatory duct (ED), which travels through the prostatic central zone and exits into the urethra (image C).
  • SV and ED have similar cell lining (image D).
  • Prostate cancer spreads to SV most often via the ED.

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