EDUCATION > Courses and Products > E-Learning > Pathology for Urologists

Pathology for Urologists

Gonadoblastoma


Image A
(click on the image above)

Image B
(click on the image above)

  • Combination of GCT and SCT.
  • Mixture of seminoma-like germ cells and immature SCT elements that resemble Sertoli cell tumor or granulosa cell tumor.
  • Extremely rare, usually encountered in patients with dysgenetic gonad.
  • Most patients are phenotypically female (80%); majority has Y chromosome.
  • During embryonic development, immature bi-potential gonads fail to differentiate along male pathway
  • 30% has bilateral testicular involvement.
  • Gross: solid yellow-tan nodules with gritty calcifications
  • Histology:
    • Well-rounded nests of large pale seminoma-like cells with abundant clear cytoplasm and well-defined cytoplasmic membranes (image A) & (image B).
    • Admixed are dark angular sex-cord cells that tend to palisade at the periphery of the tumor nests (looks like Call-Exner bodies).
    • Basement membranes can become very hyalinized and even calcified
    • Less often, nodular aggregates of Leydig cells are seen as well.
  • Immunohistochemistry: Germ cells: PLAP+, CD117+, Oct3/4+ and stromal cells: inhibin+ or calretinin+.
  • Represent pre-malignant lesions from which malignant GCTs can arise; therefore, since majority of patients have gonadal dysgenesis and therefore run a high risk of bilateral tumors, the recommended treatment is bilateral orchiectomy.

Donate
Contact
Press/Media
Sections
Term of Use
Site Map