advertisement

Home Research Research Funding AUA Funding Rising Stars in Urology Research Awards Rising Stars Award Winners

Rising Stars in Urology Research Awards

Jason Van Batavia, MD

Simpa Salami, MD, MPH
2020–2022 Award Winner

Assistant Professor, Urologic Oncology
University of Michigan

Research Project: "Radiogenomic Characterization of Prostate Cancer: Distinguishing Aggressive from Indolent Disease"
Sponsor: Astellas Pharma, US, Inc.

Abstract:
The emergence of multi-parametric magnetic resonance imaging (mpMRI) has led to significant improvement in the detection of aggressive prostate cancer with the potential of causing harm if left untreated. Although mpMRI misses about 1 in 5 of aggressive prostate cancers, this imaging modality has been rapidly adopted to make treatment decisions (e.g., selecting patients for active surveillance and for delineating areas for focal therapy). However, the biological and clinical significance of aggressive cancer areas missed by MRI or biopsy are currently unknown. The overall goal of this project is to improve the detection of aggressive prostate cancer. We have developed a novel prostate cancer-specific urine-based assay as an alternative way of making a global assessment of the prostate and believe that this approach provides a whole gland assessment. We hypothesize that a novel prostate cancer-specific urine-based assay will outperform both MRI and commercially available tissue-based genomic tests to detect aggressive disease. The successful completion of this project will provide an optimal paradigm for detecting aggressive disease using MRI and tissue/urine biomarkers in patients with newly diagnosed prostate cancer.

Jason Van Batavia, MD

Jason Van Batavia, MD
2019–2023 Award Winner

Assistant Professor, Pediatric Urology
Children's Hospital of Philadelphia

Research Project: "Role of Neuronal Subpopulations in the Pontine Micturition Center on Voiding "
Sponsor: Frank and Marion Hinman Urology Research Fund

Abstract:
Lower urinary tract symptoms (LUTS) and the conditions underlying them affect approximately 20% of school-aged children and more than 40% of adults over 40 years old, yet our understanding of how the brain controls urination is limited. The brain-bladder connection is known to go through certain command centers in the brain and brainstem, but how these areas operate is largely unknown. Our proposed research focuses on defining how specific types of nerves in the brainstem regulate this important biological function, specifically which nerves cause or prevent urination. Through these studies, we hope to identify new potential targets for novel therapies that can help both children and adults with disorders of urination.

Timothy Daskivich, MD
2018–2023 Award Winner

Assistant Professor, Department of Surgery
Cedars-Sinai Medical Center

Research Project: "A Patient-centered Approach to Integration of Life Expectancy into Treatment Decision Making for Men with Prostate Cancer"
Sponsor: Astellas Pharma, US, Inc.

Abstract:
Dr. Daskivich aims to improve the quality of life for men with prostate cancer and limited life expectancy by investigating shared decision making between patients and physicians. He will first define how life expectancy is currently communicated in treatment counseling discussions and obtain patient and physician perspectives on how it should be ideally communicated. He will then use online community perspectives on which life expectancy cutoffs are best suited to conservative treatment, and then conduct a trial to test whether a patient-centered approach to communication of life expectancy, targeted to situations where it is relevant, reduces overtreatment of prostate cancer.

Alexander W. Pastuszak

Alexander W. Pastuszak, MD, PhD
2018–2021 Award Winner

Assistant Professor, Department of Urology
Baylor College of Medicine

Research Project: : “Characterization of the Role of NELL1 in the Predisposition to Fibrosis in Peyronie's and Dupuytren's Diseases”
Sponsor: Astellas Pharma, US, Inc.

Abstract:
Dr. Pastuszak’s work is expected to improve individualized and more effective treatments for patients suffering from Peyronie’s and Dupuytren’s diseases. There is currently no cure for these heritable, superficial fibrosing diseases and treatments are only incompletely effective. Dr. Pastuszak will define the role of a gene called NELL1 in order to provide mechanistic insights into the development of these diseases. By better understanding their genetic underpinnings, Dr. Pastuszak will improve patient risk stratification leading to better patient care.

Vijaya Vemulakonda, MD
2017-2021 Award Winner

Associate Professor, Department of Urologic Surgery
University of Colorado, Health Sciences Center


Research Project: "Understanding Practice Variations in Treatment of Infants with Suspected UPJ Obstruction."
Sponsor: Frank and Marion Hinman Urology Research Fund


Abstract:
Ureteropelvic junction obstruction is a common cause of kidney dilation in children that may lead to kidney damage. The goal of surgery is to reduce the risk of kidney damage; however, surgeon variation in treatment of infants appears to be related to non-clinical patient factors and raises concerns of potential associated surgical risks that may disproportionately affect infants treated with early surgery. This project investigates the role of clinical and non-clinical patient factors on the likelihood of early treatment with surgery and establishes the framework for future studies to improve the identification of children with ureteropelvic junction obstruction who would benefit from initial surgical treatment.

Advertisement

Advertisement

advertisement

advertisement