<p><strong>Clinicians should obtain at least two needle biopsy cores per target in patients with suspicious prostate lesion(s) on MRI. (<em>Moderate Recommendation; Evidence Level: Grade C</em>)</strong></p>
Discussion
Discussion
<p>The optimal number of biopsy cores per MRI target may differ based on multiple factors including patient characteristics (e.g., age, PSA, biopsy naïve versus prior biopsy), target characteristics (e.g., size, location, PI-RADS classification), and biopsy approach/technique (e.g., software fusion versus cognitive fusion, transrectal versus transperineal).<sup>306</sup> In general, higher number of biopsy cores per target improves the CDR at the potential expense of increased complication rate and time.<sup>307</sup> However, the incremental value in cancer detection is diminished after obtaining more than three cores per target.<sup>307, 308</sup> In patients with a suspicious prostate lesion(s) by MRI, at least two needle cores per target provides the most reproducible and accurate CDR. For prostate cancer risk group stratification, all cores from the same MRI target should be considered as a single core.<sup>309</sup> </p>