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Salvage Therapy for Prostate Cancer: AUA/ASTRO/SUO Guideline (2024)

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Access FAQs on AUA clinical guideline usage and licensing.

By reading this guideline, you agree to AUA's Guidelines Terms and Conditions of Use.

Using AUA Guidelines

Access to AUA guidelines is provided free for individual clinical use only, in accordance with the AUA Guidelines Terms and Conditions of Use. Anyone accessing AUA guidelines for any other purpose must obtain a license/permission in advance. Licenses for academic, research and educational purposes (e.g., in course packs or employer-sponsored research) can be requested through the AUA by contacting permissions@AUAnet.org.

Licenses for promotional or commercial use can be requested by contacting Keith Price at kprice@AUAnet.org.

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Salvage Therapy Prostate Cancer Guideline PDF

The Journal of Urology® Article Part I

The Journal of Urology® Article Part II

The Journal of Urology® Article Part III


Purpose

While definitive standard of care therapies cure most patients with clinically localized prostate cancer, the risk of recurrence, and even subsequent metastasis, is over 50% in patients with the highest disease risk features. Understanding the evaluation and appropriate use of salvage therapies for patients with biochemical recurrence is a critical area of prostate cancer care. In fact, a cure is still possible for many of these patients.

Key Takeaways

Balancing undertreatment with overtreatment, utilizing new therapeutic agents and imaging modalities, and optimizing patient selection through use of evidence-driven prognostic markers are all critical to improving oncologic outcomes and maintaining quality of life for these patients. The clinical guideline includes discussion of the following:

  • Treatment decision-making at the time of suspected biochemical recurrence after primary radical prostatectomy
  • Treatment delivery for non-metastatic biochemical recurrence after primary radical prostatectomy
  • Evaluation and management of suspected non-metastatic recurrence after radiation therapy
  • Evaluation and management of suspected non-metastatic recurrence after focal therapy
  • Evaluation and management of regional recurrence
  • Management for molecular imaging metastatic recurrence

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AUA Clinical Practice Guidelines are developed by multidisciplinary panels of experts based on rigorous systematic review of current urologic research.